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1

Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegenerative disease models

Umezawa, Kazuo, Kojima, Itaru, Simizu, Siro, Lin, Yinzhi, Fukatsu, Hitomi, Koide, Naoki, Nakade, Yukiomi, Yoneda, Masashi

Journal:

Year:

2017

Language:

english

File:

PDF, 852 KB

english, 2017

2

A novel metal-Chelating inhibitor of protein farnesyltransferase

Akiyuki Hamasaki, Hayato Naka, Fuyuhiko Tamanoi, Kazuo Umezawa, Masami Otsuka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 214 KB

english, 2003

3

Induction of sister chromatid exchanges by nicotinamide in Chinese hamster lung fibroblasts and human lymphoblastoid cells

Tadashi Utakoji, Keiko Hosoda, Kazuo Umezawa, Mutsuko Sawamura, Taijiro Matsushima, Masanao Miwa, Takashi Sugimura

Journal:

Biochemical and Biophysical Research Communications

Year:

1979

Language:

english

File:

PDF, 352 KB

english, 1979

4

Phenacyl photosensitive blocking groups

Sheehan, John C., Umezawa, Kazuo

Journal:

Journal of Organic Chemistry

Year:

1973

Language:

english

File:

PDF, 557 KB

english, 1973

5

Novel approaches to target NF-κB and other signaling pathways in cancer stem cells

Ukaji, Tamami, Umezawa, Kazuo

Journal:

Advances in Biological Regulation

Year:

2014

Language:

english

File:

PDF, 1.02 MB

english, 2014

6

[IEEE 2019 IEEE International Symposium on Technologies for Homeland Security (HST) - Woburn, MA, USA (2019.11.5-2019.11.6)] 2019 IEEE International Symposium on Technologies for Homeland Security (HST) - Threat analyses using vulnerability databases âPossibility of utilizing past analysis resultsâ

Umezawa, Katsuyuki, Mishina, Yusuke, Takaragi, Kazuo

Year:

2019

Language:

english

File:

PDF, 4.24 MB

english, 2019

7

ChemInform Abstract: Polyoxypeptins A and B Produced by Streptomyces: Apoptosis-Inducing Cyclic Depsipeptides Containing the Novel Amino Acid (2S,3R)-3-Hydroxy-3-methylproline.

Kazuo Umezawa, Kumi Nakazawa, Yoko Ikeda, Hiroshi Naganawa, Shinichi Kondo

Journal:

Year:

1999

File:

PDF, 30 KB

1999

8

[IEEE 2018 IEEE International Symposium on Technologies for Homeland Security (HST) - Woburn, MA, USA (2018.10.23-2018.10.24)] 2018 IEEE International Symposium on Technologies for Homeland Security (HST) - A Method of Threat Analysis for Cyber-Physical System using Vulnerability Databases

Mishina, Yusuke, Takaragi, Kazuo, Umezawa, Katsuyuki

Year:

2018

Language:

english

File:

PDF, 373 KB

english, 2018

9

Analysis of gene expression profiles in Arabidopsis salt overly sensitive mutants sos2−1 and sos3 −1

AYAKO KAMEI, MOTOAKI SEKI, TAISHI UMEZAWA, JUNKO ISHIDA, MASAKAZU SATOU, KENJI AKIYAMA, JIAN-KANG ZHU, KAZUO SHINOZAKI

Journal:

Plant, Cell & Environment

Year:

2005

Language:

english

File:

PDF, 154 KB

english, 2005

10

Production, isolation and structure determination of a novel .BETA.-glucosidase inhibitor, cyclophellitol, from Phellinus sp.

ATSUMI, SONOKO, UMEZAWA, KAZUO, IINUMA, HIRONOBU, NAGANAWA, HIROSHI, NAKAMURA, HIKARU, IITAKA, YOICHI, TAKEUCHI, TOMIO

Journal:

The Journal of Antibiotics

Year:

1990

Language:

english

File:

PDF, 270 KB

english, 1990

11

A new bioactive steroidal saponin, furcreastatin, from the plant Furcraea foetida

Masaki Itabashi, Kaoru Segawa, Yoko Ikeda, Shinichi Kondo, Hiroshi Naganawa, Takashi Koyano, Kazuo Umezawa

Journal:

Carbohydrate Research

Year:

1999

Language:

english

File:

PDF, 95 KB

english, 1999

12

Biological activities of cyclophellitol.

ATSUMI, SONOKO, IINUMA, HIRONOBU, NOSAKA, CHISATO, UMEZAWA, KAZUO

Journal:

The Journal of Antibiotics

Year:

1990

Language:

english

File:

PDF, 518 KB

english, 1990

13

[IEEE 2019 IEEE International Conference on Pervasive Computing and Communications Workshops (PerCom Workshops) - Kyoto, Japan (2019.3.11-2019.3.15)] 2019 IEEE International Conference on Pervasive Computing and Communications Workshops (PerCom Workshops) - Competitive Compliance with Blockchain

Wohlgemuth, Sven, Umezawa, Katsuyuki, Mishina, Yusuke, Takaragi, Kazuo

Year:

2019

Language:

english

File:

PDF, 893 KB

english, 2019

14

Corrigendum to “poly (ADP-ribose) polymerase inhibition synergizes with the NF-κB inhibitor DHMEQ to kill hepatocellular carcinoma cells” [Biochim. Biophys. Acta 1853(12)(2015) 3224–3234]

Lampiasi, Nadia, Umezawa, Kazuo, Montalto, Giuseppe, Cervello, Melchiorre

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2018

Language:

english

File:

PDF, 171 KB

english, 2018

15

Design, synthesis, and biological evaluation of novel estradiol–bisphosphonate conjugates as bone-specific estrogens

Masahiko Morioka, Akihito Kamizono, Hirosato Takikawa, Akihisa Mori, Hiroaki Ueno, Shu-ichiro Kadowaki, Yoshihide Nakao, Kuniki Kato, Kazuo Umezawa

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 452 KB

english, 2010

16

Chemoenzymatic synthesis of (2S,3S,4S)-form, the physiologically active stereoisomer of dehydroxymethylepoxyquinomicin (DHMEQ), a potent inhibitor on NF-κB

Manabu Hamada, Yukihiro Niitsu, Chihiro Hiraoka, Ikuko Kozawa, Toshinori Higashi, Mitsuru Shoji, Kazuo Umezawa, Takeshi Sugai

Journal:

Year:

2010

Language:

english

File:

PDF, 527 KB

english, 2010

17

Polyoxypeptin isolated from Streptomyces: A bioactive cyclic depsipeptide containing the novel amino acid 3-hydroxy-3-methylproline

Kazuo Umezawa, Kumi Nakazawa, Toshio Uemura, Yoko Ikeda, Shinichi Kondo, Hiroshi Naganawa, Naoko Kinoshita, Hideki Hashizume, Masa Hamada, Tomio Takeuchi, Shigeru Ohba

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 268 KB

english, 1998

18

Identification of the replication region of Lactobacillus acidophilus plasmid pLA103

Kazuo Kanatani, Takatsugu Tahara, Masao Oshimura, Keiji Sano, Chisae Umezawa

Journal:

FEMS Microbiology Letters

Year:

1995

Language:

english

File:

PDF, 321 KB

english, 1995

19

Inhibition of epidermal growth factor receptor functions by tyrosine kinase inhibitors in NIH3T3 cells

Kazuo Umezawa, Daiji Sugata, Katsuyuki Yamashita, Noriko Johtoh, Masabumi Shibuya

Journal:

Year:

1992

Language:

english

File:

PDF, 597 KB

english, 1992

20

Identification of the replication region of Lactobacillus acidophilus plasmid pLA103

Kazuo Kanatani, Takatsugu Tahara, Masao Oshimura, Keiji Sano, chisae Umezawa

Journal:

FEMS Microbiology Letters

Year:

1995

Language:

english

File:

PDF, 337 KB

english, 1995

21

Screening of bioactive metabolites for pancreatic regeneration chemotherapy

Hiroshi Takatsuna, Kazuo Umezawa

Journal:

Biomedicine & Pharmacotherapy

Year:

2004

Language:

english

File:

PDF, 305 KB

english, 2004

22

1052 DOES NF-KB ACTIVATION INHIBITOR, DHMEQ OVERCOME THE CHEMORESISTANCE TO CISPLATIN IN BLADDER CANCER?

Gondo, Tatsuo, Horiguchi, Yutaka, Hashimoto, Takeshi, Nakashima, Jun, Tachibana, Masaaki, Kikuchi, Eiji, Oya, Mototsugu, Suzuki, Eriko, Umezawa, Kazuo

Journal:

The Journal of Urology

Year:

2011

Language:

english

File:

PDF, 42 KB

english, 2011

23

Adenylate Cyclase from Brevibacterium liquefaciens. III. in situ Regulation of Adenylate Cyclase by Pyruvate

Kazuo Umezawa, Katsuji Takai, Shoji Tsuji, Yoshikazu Kurashina and Osamu Hayaishi

Journal:

Proceedings of the National Academy of Sciences

Year:

1974

Language:

english

File:

PDF, 632 KB

english, 1974

24

DSE-FRET: A new anticancer drug screening assay for DNA binding proteins

Miyagi, Toru, Shiotani, Bunsyo, Miyoshi, Ryuya, Yamamoto, Takuya, Oka, Takanori, Umezawa, Kazuo, Ochiya, Takahiro, Takano, Mikihisa, Tahara, Hidetoshi

Journal:

Year:

2014

Language:

english

File:

PDF, 1007 KB

english, 2014

25

Synthesis and Inhibitory Activity Against Phosphatidylinositol 4-Kinase of Echiguanine Analogs

Saito, Yoshio, Kato, Kuniki, Umezawa, Kazuo

Journal:

Nucleosides and Nucleotides

Year:

1999

Language:

english

File:

PDF, 136 KB

english, 1999

26

Novel Design for Electromagnet with Wide Excitation Range

Iwashita, Yoshihisa, Noda, Akira, Shirai, Toshiyuki, Morita, Akio, Tadokoro, Masahiro, Hirota, Jun'ichi, Umezawa, Masami, Hiramoto, Kazuo

Journal:

Japanese Journal of Applied Physics

Year:

1999

Language:

english

File:

PDF, 127 KB

english, 1999

27

Brefeldin A exerts differential effects on anaplastic lymphoma kinase positive anaplastic large cell lymphoma and classical Hodgkin lymphoma cell lines

Toda, Takashi, Watanabe, Mariko, Kawato, Junji, Kadin, Marshall E., Higashihara, Masaaki, Kunisada, Takao, Umezawa, Kazuo, Horie, Ryouichi

Journal:

British Journal of Haematology

Year:

2015

Language:

english

File:

PDF, 1.27 MB

english, 2015

28

Variation in oxygen isotope ratio of dissolved orthophosphate induced by uptake process in natural coral holobionts

Ferrera, Charissa M., Miyajima, Toshihiro, Watanabe, Atsushi, Umezawa, Yu, Morimoto, Naoko, San Diego-McGlone, Maria Lourdes, Nadaoka, Kazuo

Journal:

Year:

2016

Language:

english

File:

PDF, 1.12 MB

english, 2016

29

ON THE MECHANISM OF ACTION OF BLEOMYCIN : SCISSION OF DNA STRANDS IN VITRO AND IN VIVO

SUZUKI, HIDEO, NAGAI, KAZUO, YAMAKI, HIROSHI, TANAKA, NOBUO, UMEZAWA, HAMAO

Journal:

The Journal of Antibiotics

Year:

1969

Language:

english

File:

PDF, 411 KB

english, 1969

30

Enantiospecific synthesis and biological evaluation of 1,6-epi-cyclophellitol.

TATSUTA, KUNIAKI, NIWATA, YOSHIHISA, UMEZAWA, KAZUO, TOSHIMA, KAZUNOBU, NAKATA, MASAYA

Journal:

The Journal of Antibiotics

Year:

1991

Language:

english

File:

PDF, 185 KB

english, 1991

31

Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. II. Structure determination.

KAKEYA, HIDEAKI, IMOTO, MASAYA, TAKAHASHI, YOSHIKAZU, NAGANAWA, HIROSHI, TAKEUCHI, TOMIO, UMEZAWA, KAZUO

Journal:

The Journal of Antibiotics

Year:

1993

Language:

english

File:

PDF, 185 KB

english, 1993

32

Simultaneous and multi-point measurement of ammonia emanating from human skin surface for the estimation of whole body dermal emission rate

Furukawa, Shota, Sekine, Yoshika, Kimura, Keita, Umezawa, Kazuo, Asai, Satomi, Miyachi, Hayato

Journal:

Journal of Chromatography B

Year:

2017

Language:

english

File:

PDF, 951 KB

english, 2017

33

The Unfolded Protein Response Mediated by PERK is casually related to the Pathogenesis of Intervertebral Disc Degeneration

Fujii, Takeshi, Fujita, Nobuyuki, Suzuki, Satoshi, Tsuji, Takashi, Takaki, Takashi, Umezawa, Kazuo, Watanabe, Kota, Miyamoto, Takeshi, Horiuchi, Keisuke, Matsumoto, Morio, Nakamura, Masaya

Journal:

Journal of Orthopaedic Research

Year:

2017

Language:

english

File:

PDF, 724 KB

english, 2017

34

Inhibition of CDP-DG:Inositol Transferase by Inostamycin1

Imoto, Masaya, Taniguchi, Yoshiko, Umezawa, Kazuo

Journal:

Journal of Biochemistry

Year:

1992

Language:

english

File:

PDF, 1.63 MB

english, 1992

35

ChemInform Abstract: Syntheses of Oxanosine and Carbocyclic Oxanosine Derivatives as anti-HIV Agents.

Yoshio Saito, Mariko Nakamura, Tsuneya Ohno, Chanya Chaicharoenpong, Eiko Ichikawa, Shosuke Yamamura, Kuniki Kato, Kazuo Umezawa

Journal:

Year:

2000

File:

PDF, 34 KB

2000

36

Designed ATRA analogue active against ATRA-resistant acute promyelocytic leukemia cells having a single nucleotide substitution in their retinoic acid receptor

Naoyuki Komura, Yoko Ikeda, Natsuko Masuda, Yoji Umezawa, Keisuke Ito, Masahiro Kizaki, Kazuo Umezawa

Journal:

Leukemia Research

Year:

2007

Language:

english

File:

PDF, 4.06 MB

english, 2007

37

Tyrosine kinase inhibitor, methyl 2,5-dihydromethylcinnimate, induces PML nuclear body formation and apoptosis in tumor cells

Naoyuki Komura, Mayako Asakawa, Kazuo Umezawa, Kaoru Segawa

Journal:

Experimental Cell Research

Year:

2007

Language:

english

File:

PDF, 1.49 MB

english, 2007

38

Similarity of teleocidin B and phorbol ester tumour promoters in effects on membrane receptors

Umezawa, Kazuo, Weinstein, I. Bernard, Horowitz, Ann, Fujiki, Hirota, Matsushima, Taijiro, Sugimura, Takashi

Journal:

Year:

1981

File:

PDF, 381 KB

1981

39

A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice

Tohru Funakoshi, Kenichiro Yamashita, Nobuki Ichikawa, Moto Fukai, Tomomi Suzuki, Ryoichi Goto, Tetsu Oura, Nozomi Kobayashi, Takehiko Katsurada, Shin Ichihara, Michitaka Ozaki, Kazuo Umezawa, Satoru

Journal:

Journal of Crohn's and Colitis

Year:

2012

Language:

english

File:

PDF, 1.41 MB

english, 2012

40

Isolation of Novel Saquayamycins as Inhibitors of Farnesyl-protein Transferase.

SEKIZAWA, RYUICHI, IINUMA, HIRONOBU, NAGANAWA, HIROSHI, HAMADA, MASA, TAKEUCHI, TOMIO, YAMAIZUMI, JIRO, UMEZAWA, KAZUO

Journal:

The Journal of Antibiotics

Year:

1996

Language:

english

File:

PDF, 245 KB

english, 1996

41

MECHANISM OF ACTION OF NEGAMYCIN IN ESCHERICHIA COLI K 12

MIZUNO, SATOSHI, NITTA, KAZUO, UMEZAWA, HAMAO

Journal:

The Journal of Antibiotics

Year:

1970

Language:

english

File:

PDF, 413 KB

english, 1970

42

Syntheses of Oxanosine and Carbocyclic Oxanosine Derivatives as Anti-HIV Agents.

SAITO, YOSHIO, NAKAMURA, MARIKO, OHNO, TSUNEYA, CHAICHAROENPONG, CHANYA, ICHIKAWA, EIKO, YAMAMURA, SHOSUKE, KATO, KUNIKI, UMEZAWA, KAZUO

Journal:

The Journal of Antibiotics

Year:

2000

Language:

english

File:

PDF, 246 KB

english, 2000

43

Inhibition of NF-κB Activity Enhances Sensitivity to Anticancer Drugs in Cholangiocarcinoma Cells

Seubwai, Wunchana, Vaeteewoottacharn, Kulthida, Kraiklang, Ratthaphol, Umezawa, Kazuo, Okada, Seiji, Wongkham, Sopit

Journal:

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

Year:

2016

Language:

english

File:

PDF, 1.14 MB

english, 2016

44

Effects of a novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), on growth, apoptosis, gene expression, and chemosensitivity in head and neck squamous cell carcinoma cell lines

Hong-ying Ruan, Muneyuki Masuda, Aya Ito, Kazuo Umezawa, Torahiko Nakashima, Ryuji Yasumatsu, Yuichiro Kuratomi, Tomoya Yamamoto, I. Bernard Weinstein, Shizuo Komune

Journal:

Year:

2006

Language:

english

File:

PDF, 194 KB

english, 2006

45

Reversal of anticancer drug resistance by COTC based on intracellular glutathione and glyoxalase I

Daisuke Kamiya, Yuki Uchihata, Eiko Ichikawa, Kuniki Kato, Kazuo Umezawa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 233 KB

english, 2005

46

Effects of inhibitors of protein tyrosine kinase activity and/or phosphatidylinositol turnover on differentiation of some human myelomonocytic leukemia cells

Makoto Makishima, Yoshio Honma, Motoo Hozumi, Kazumi Sampi, Masao Hattori, Kazuo Umezawa, Kazuo Motoyoshi

Journal:

Leukemia Research

Year:

1991

Language:

english

File:

PDF, 1.82 MB

english, 1991

47

Induction of Hydrogen Peroxide Production and Bax Expression by Caspase-3(-Like) Proteases in Tyrosine Kinase Inhibitor-Induced Apoptosis in Human Small Cell Lung Carcinoma Cells

Siro Simizu, Kazuo Umezawa, Minoru Takada, Nadir Arber, Masaya Imoto

Journal:

Experimental Cell Research

Year:

1998

Language:

english

File:

PDF, 366 KB

english, 1998

48

Induction by fibroblast growth factor of angiotensin converting enzyme in vascular endothelial cells in vitro

Tetsuro Okabe, Kazuo Yamagata, Michio Fujisawa, Fumimaro Takaku, Hiroshi Hidaka, Yoshimi Umezawa

Journal:

Biochemical and Biophysical Research Communications

Year:

1987

Language:

english

File:

PDF, 307 KB

english, 1987

49

Enhancement of haemolysis and cellular arachidonic acid release by pyrrolomycins

Kazuo Umezawa, Sanae Mimura, Taijiro Matsushima, Shigemi Muramatsu, Tsutomu Sawa, Tomio Takeuchi

Journal:

Biochemical and Biophysical Research Communications

Year:

1982

Language:

english

File:

PDF, 285 KB

english, 1982

50

Screening for inducers of apoptosis in apoptosis-resistant human carcinoma cells

Kazuo Umezawa, Kumi Nakazawa, Yuki Uchihata, Masami Otsuka

Journal:

Advances in Enzyme Regulation

Year:

1999

Language:

english

File:

PDF, 164 KB

english, 1999

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